The Human Achaete-Scute Homologue 2 (ASCL2, HASH2) Maps to Chromosome 11p15.5, Close to IGF2 and is Expressed in Extravillus Trophoblasts

M Alders, M Hodges, AK Hadjantonakis… - Human molecular …, 1997 - academic.oup.com
human Achaete Scute Homologue 2 (HASH2) gene, officially designated … (human Achaete
Scute homologue 2). We show that HASH2 maps proximal to, and in close proximity of, IGF2

The Human ASCL2 Gene Escaping Genomic Imprinting and Its Expression Pattern

T Miyamoto, S Hasuike, Y Jinno, H Soejima… - Journal of assisted …, 2002 - Springer
achaete-scute homolog-2 gene (Ascl2 or Mash2) encodes a transcription factor playing a role
in the development of the trophoblast. … (9) within ICR close to IGF2, H19, and p57KIP2 (10). …

JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2)

D Zhang, HG Yoon, J Wong - Molecular and cellular biology, 2005 - Taylor & Francis
… The ASCL2 gene has been mapped to human chromosome … of the IGF2 and KCNQ1 genes
were expressed and paternal … in the extraembryonic trophoblast lineage but repressed in …

Characterization of the placenta specific bovine mammalian achaete scute-like homologue 2 (Mash2) gene

DR Arnold, R Lefebvre, LC Smith - Placenta, 2006 - Elsevier
… (Mash2; also known as Ascl2). The Mash2 gene, a mammalian … Analogous to the mouse,
human Hash2 is only expressed in the extravillus trophoblast and has been mapped to the …

The IPL Gene on Chromosome 11p15.5 is Imprinted in Humans and Mice and is Similar to TDAG51 , Implicated in Fas Expression and …

N Qian, D Frank, D O'Keefe, D Dao… - Human Molecular …, 1997 - academic.oup.com
… Mouse Ipl maps to the region of chromosome 7 which is … We next validated the SSCP and
Alu I RFLP methods for … maternally repressed/paternally expressed genes [ IGF2 , the insulin …

Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting

MP Lee, S Brandenburg, GM Landes… - Human molecular …, 1999 - academic.oup.com
… regulates IGF2 (6); (iii) ASCL2, a homolog of Drosophila achaete-scute expressed in the
trophoblast (7… We previously reported the mapping and isolation of 13 genes within an STF from …

The Human Achaete Scute Homolog 2 gene contains two promotors, generating overlapping transcripts and encoding two proteins with different nuclear localization

BA Westerman, A Poutsma, LHJ Looijenga, D Wouters… - Placenta, 2001 - Elsevier
… , within the imprinting cluster close to Ins, Igf2 and H19. Both … of the expression and imprinting
status of HASH2 as … 1 is present in normal extravillus trophoblast cells and other cells as …

A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15. 5, and isolation and sequence analysis of three novel genes

RJ Hu, MP Lee, TD Connors, LA Johnson, TC Burn… - Genomics, 1997 - Elsevier
… TH (tyrosine hydroxylase), INS (insulin), IGF2, and H19 are four genes … Human achaete-scute
homolog 2 (ASCL2). A human homologue of mouse achaete-scute homologue 2

Imprinted genes in the placenta–a review

PM Coan, GJ Burton, AC Ferguson-Smith - Placenta, 2005 - Elsevier
… , is found in invasive extravillous trophoblast (iEVT), similar to … HASH2 the human homologue
of Mash2 is expressed by early … expression of IGF2 in human syncytial trophoblast although …

Paternally inherited submicroscopic duplication at 11p15. 5 implicates insulin-like growth factor II in overgrowth and Wilms' tumorigenesis

EM Algar, L St. Heaps, A Darmanian, V Dagar… - Cancer research, 2007 - AACR
… artificial chromosome array. IGFII is the only known paternally expressed oncogene mapping
… However, effective dosage of maternally expressed genes, including H19 and ASCL2 (25), …